Lawrence Steinman Selected Research

Proteins (Proteins, Gene)

1/2023	Experimental encephalomyelitis at age 90, still relevant and elucidating how viruses trigger disease.
1/2021	Generating tumor-selective conditionally active biologic anti-CTLA4 antibodies via protein-associated chemical switches.
1/2020	A sugar-coated strategy to treat a rare neurologic disease provides a blueprint for a decoy glycan therapeutic and a potential vaccine for CoViD-19: An Editorial Highlight for "Selective inhibition of anti-MAG IgM autoantibody binding to myelin by an antigen specific glycopolymer"on page 486.
12/2019	Antigen-specific tolerance to self-antigens in protein replacement therapy, gene therapy and autoimmunity.
1/2018	Engineered DNA plasmid reduces immunity to dystrophin while improving muscle force in a model of gene therapy of Duchenne dystrophy.
12/2016	Mechanistic insights into influenza vaccine-associated narcolepsy.
1/2016	Identification of Candidate Tolerogenic CD8(+) T Cell Epitopes for Therapy of Type 1 Diabetes in the NOD Mouse Model.
7/2015	Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2.
4/2015	No quiet surrender: molecular guardians in multiple sclerosis brain.
4/2013	Amyloid fibrils composed of hexameric peptides attenuate neuroinflammation.

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Lawrence Steinman Research Topics

Disease

109	Multiple Sclerosis 01/2023 - 01/2002
61	Experimental Autoimmune Encephalomyelitis (Encephalomyelitis, Autoimmune Experimental) 11/2023 - 05/2002
35	Autoimmune Diseases (Autoimmune Disease) 01/2023 - 01/2002
28	Inflammation (Inflammations) 11/2023 - 04/2006
22	Neuroinflammatory Diseases 02/2024 - 06/2003
19	Paralysis (Palsy) 12/2017 - 11/2002
17	Demyelinating Diseases (Demyelinating Disease) 11/2023 - 11/2002
14	Neoplasms (Cancer) 10/2022 - 06/2002
12	Neuromyelitis Optica (Devic's Disease) 12/2019 - 10/2009
10	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 12/2019 - 04/2002
9	Rheumatoid Arthritis 12/2019 - 03/2002
9	Relapsing-Remitting Multiple Sclerosis 12/2013 - 09/2002
8	Disease Progression 11/2019 - 09/2002
7	Encephalomyelitis (Myeloencephalitis) 01/2023 - 09/2003
7	Infections 01/2022 - 02/2007
6	Encephalitis (Encephalitis, Rasmussen) 01/2019 - 01/2006
6	Narcolepsy 12/2016 - 01/2011
6	Systemic Lupus Erythematosus (Libman-Sacks Disease) 03/2015 - 03/2002
5	COVID-19 12/2022 - 01/2020
5	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2018 - 06/2003
5	Human Influenza (Influenza) 12/2016 - 05/2014
5	Brain Diseases (Brain Disorder) 12/2015 - 01/2007
4	Progressive Multifocal Leukoencephalopathy 01/2021 - 06/2005
4	Stroke (Strokes) 01/2019 - 08/2011
4	Alzheimer Disease (Alzheimer's Disease) 07/2014 - 06/2003
4	Arthritis (Polyarthritis) 01/2010 - 10/2006
3	Autoimmune Diseases of the Nervous System 03/2024 - 10/2011
3	Measles 01/2023 - 06/2002
3	Ischemia 01/2019 - 06/2011
3	Huntington Disease (Huntington's Disease) 01/2018 - 01/2002
3	Atherosclerosis 02/2016 - 12/2005
3	Hypersensitivity (Allergy) 12/2014 - 11/2003
3	Nervous System Diseases (Neurological Disorders) 05/2014 - 09/2011
3	Necrosis 12/2009 - 11/2002
3	Anaphylaxis (Anaphylactic Shock) 04/2009 - 02/2003
3	Experimental Arthritis 01/2008 - 10/2006
2	Gliosis 11/2023 - 01/2017
2	Adrenoleukodystrophy (Adrenoleukodystrophy, X-Linked) 11/2023 - 04/2023

Drug/Important Bio-Agent (IBA)

30	AntigensIBA 01/2020 - 04/2002
24	Proteins (Proteins, Gene)FDA Link 01/2023 - 01/2002
21	AntibodiesIBA 01/2023 - 01/2006
21	Peptides (Polypeptides)IBA 01/2019 - 12/2002
20	CytokinesIBA 01/2019 - 05/2002
17	AutoantibodiesIBA 01/2020 - 01/2002
15	VaccinesIBA 01/2023 - 04/2002
15	AutoantigensIBA 01/2023 - 03/2002
15	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 05/2014 - 11/2002
11	Natalizumab (Tysabri)FDA Link 01/2023 - 06/2005
10	InterferonsIBA 01/2023 - 11/2002
10	Crystallins (Crystallin)IBA 01/2019 - 07/2007
10	Amyloid (Amyloid Fibrils)IBA 01/2018 - 08/2012
8	DNA VaccinesIBA 05/2014 - 09/2003
7	EpitopesIBA 01/2020 - 10/2003
7	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 04/2002
6	ozanimodIBA 10/2022 - 01/2019
6	EnzymesIBA 01/2021 - 02/2006
6	Small Heat-Shock ProteinsIBA 01/2018 - 03/2012
6	Insulin (Novolin)FDA Link 01/2016 - 02/2003
6	Interleukin-6 (Interleukin 6)IBA 08/2014 - 05/2002
6	Atorvastatin (Lipitor)FDA Link 02/2014 - 11/2002
6	Interleukin-17 (Interleukin 17)IBA 11/2013 - 02/2007
5	Monoclonal AntibodiesIBA 02/2024 - 06/2005
5	Glatiramer Acetate (Copaxone)FDA Link 01/2023 - 09/2002
5	Biomarkers (Surrogate Marker)IBA 11/2021 - 06/2006
5	LipidsIBA 04/2015 - 09/2005
5	Interferon-betaIBA 08/2013 - 09/2002
5	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2013 - 11/2002
4	Vitamin D FDA LinkGeneric 04/2023 - 03/2011
4	Immunoglobulin G (IgG)IBA 01/2023 - 04/2009
4	Polysaccharides (Glycans)IBA 01/2020 - 03/2009
4	Amino Acids FDA Link 12/2015 - 04/2013
4	LigandsIBA 07/2015 - 09/2005
4	Histamine (Histamine Dihydrochloride)FDA Link 12/2014 - 01/2006
4	Transforming Growth Factor beta (TGF-beta)IBA 08/2010 - 08/2007
4	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 12/2009 - 10/2007
3	Alemtuzumab (Campath)FDA Link 01/2023 - 01/2017
3	OsteopontinIBA 01/2023 - 01/2007
3	Antiviral Agents (Antivirals)IBA 01/2023 - 10/2003
3	Myelin ProteinsIBA 01/2018 - 10/2007
3	Amyloidogenic ProteinsIBA 01/2018 - 07/2014
3	ProinsulinIBA 01/2018 - 06/2013
3	Orexin ReceptorsIBA 12/2016 - 07/2015
3	pandemrixIBA 12/2016 - 07/2015
3	NucleoproteinsIBA 12/2016 - 07/2015
3	Influenza Vaccines (Influenza Vaccine)FDA Link 12/2016 - 11/2015
3	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 01/2016 - 02/2003
3	Heat-Shock Proteins (Heat-Shock Protein)IBA 04/2015 - 10/2007
3	Histamine Receptors (Histamine Receptor)IBA 12/2014 - 02/2003
3	Therapeutic UsesIBA 02/2014 - 08/2007
3	Tryptophan (L-Tryptophan)FDA Link 01/2014 - 11/2005
3	GpG-oligonucleotideIBA 03/2010 - 11/2003
3	CholesterolIBA 07/2008 - 05/2006
3	Oxidoreductases (Dehydrogenase)IBA 10/2007 - 12/2005
2	CuprizoneIBA 11/2023 - 01/2017
2	Cholecalciferol (Vitamin D3)FDA Link 04/2023 - 01/2016
2	25-hydroxyvitamin DIBA 04/2023 - 03/2011
2	teriflunomideIBA 01/2023 - 01/2022

Therapy/Procedure

57	Therapeutics 11/2023 - 01/2002
7	Immunotherapy 10/2022 - 02/2003
3	Drug Therapy (Chemotherapy) 10/2022 - 09/2002